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Research

Research

Active Studies

Maternal hyperoxygenation for fetal borderline left heart structures
We are studying fetuses that have borderline left heart structures, and examining whether having mothers wear oxygen during the third trimester of pregnancy can help improve fetal lung blood flow, which can help deliver more blood to the left side of the heart, resulting in improved left heart growth and improved brain development.

  • Principal Investigators: Dr. Shaine Morris and Dr. Judith Becker. 
  • To be evaluated for eligibility or for questions, contact Teniola Shittu at 832-826-5613.

Fetal atrial flutter & supraventricular tachycardia (FAST) therapy trial
We are part of an international study evaluating the best treatments for fetal supraventricular tachycardia and atrial flutter.

  • Principal Investigators: Dr. Nancy Ayres and Dr. Shaine Morris
  • To be evaluated for eligibility or for questions, contact Christie Moran or Carol Roth at 832-822-2229.

Fetal cardiac interventions
We are studying the outcomes after fetal cardiac intervention, including:

  1. Aortic valvuloplasty for fetal aortic stenosis/evolving hypoplastic left heart syndrome
  2. Atrial septal dilation or stenting for fetal hypoplastic left heart syndrome with intact or restrictive atrial septum
  3. Pulmonary valvuloplasty for severe pulmonary stenosis/near pulmonary atresia
  • Principal Investigator: Dr. Shaine Morris
  • To be evaluated for eligibility or for questions, contact Christie Moran or Carol Roth at 832-822-2229.

Prenatal Predictors of Postnatal Outcome in Pulmonary Atresia with Intact Ventricular Septum, Fetal Heart Society Collaborative Project

  • Principal Investigator: Dr. S. Kristen Sexson Tejtel
  • For questions, contact 832-82-HEART (832-824-3278).

Mitral Valve Regurgitation in the Fetus, Fetal Heart Society Collaborative Project

  • Principal Investigators: Dr. Betul Yilmaz Furtun and Dr. Shaine Morris
  • For questions, contact 832-82-HEART (832-824-3278).

Impact of socioeconomic and geographic factors on prenatal diagnosis of hypoplastic left heart syndrome (HLHS) and d-transposition of the great arteries (d-TGA), Fetal Heart Society Collaborative Project

  • Principal Investigator: Dr. Keila Lopez
  • For questions, contact 832-82-HEART (832-824-3278).

Fetal anatomy and physiology and associations with fetal and perinatal outcomes in D-transposition of the great arteries with intact ventricular septum, a multicenter, multi-arm, prospective study, Fetal Heart Society Collaborative Project

  • Principal Investigators: Dr. Shaine Morris, Dr. Judith Becker, Dr. Shreya Sheth, Dr. John Colquitt
  • For questions, contact 832-82-HEART (832-824-3278).

Fetal Cardiology Publications

2017

Edwards L, Masand P, Morris SA. Atypical Circular Shunt and Diffuse Emphysema in a Fetus with Double Outlet Right Ventricle and Absent Pulmonary Valve, Case: Cardiovascular Imaging Case Reports, in press.

Jantzen DW*, Moon-Grady AJ, Morris SA, Armstrong AK, Berg C, Joanna Dangel, Carlen G. Fifer, Michele Frommelt, Ulrich Gembruch, Ulrike Herberg, Edgar Jaeggi, Eftichia V. Kontopoulos, Owen Miller, Renate Oberhoffer, Carlos A. Pedra, Simone R. Pedra, Fabio Peralta, Ruben A. Quintero, Greg Ryan, Sarah K. Gelehrter,. Hypoplastic Left Heart Syndrome with Intact or Restrictive Atrial Septum: a Report from the International Fetal Cardiac Intervention Registry. Circulation, in press.

Kailin JA, Dhillon GS, Maskatia SA, Cass DL, Shamshirsaz AA, Mehollin-Ray AR, Cassady CI, Ayres NA, Wang Y, Belfort MA, Olutoye OO, Ruano R. Fetal left-sided cardiac structural dimensions in left-sided congenital diaphragmatic hernia - association with severity and impact on postnatal outcomes. Prenat Diagn. 2017 May;37(5):502-509. doi: 10.1002/pd.5045. Epub 2017 Apr 27. PubMed PMID: 28370263.  

Lara DA, Ethen MK, Canfield MA, Nembhard WN, Morris SA. A population-based analysis of mortality in patients with Turner syndrome and hypoplastic left heart syndrome using the Texas Birth Defects Registry. Congenit Heart Dis. 2017 Jan;12(1):105-112. Epub 2016 Sep 29. PubMed PMID: 27685952.

Maskatia SA, Lee W, Altman CA, Ayres NA, Feagin DK, Pignatelli RH. Left ventricular rotational mechanics in early infancy: Normal reference ranges and reproducibility of peak values and time to peak values. Early Hum Dev. 2017 Jan;104:39-44. Epub 2016 Dec 30. PubMed PMID: 28042971.

Mery CM, Nieto RM, De León LE, Morris SA, Zhang W, Colquitt JL, Adachi I, Kane LC, Heinle JS, McKenzie ED, Fraser CD Jr. The Role of Echocardiography and Intracardiac Exploration in the Evaluation of Candidacy for Biventricular Repair in Patients With Borderline Left Heart Structures. Ann Thorac Surg. 2017 Mar;103(3):853-861. doi: 10.1016/j.athoracsur.2016.07.043. Epub 2016 Oct 4. PubMed PMID: 27717424.

Nassr AA, Shazly SA, Morris SA, Ayres N, Espinoza J, Erfani H, Olutoye OA, Sexson SK, Olutoye OO, Fraser CD Jr, Belfort MA, Shamshirsaz AA. Antenatal Management of Fetal Intrapericardial Teratoma: A Systematic Review. Prenat Diagn. 2017 Jul 10. doi: 10.1002/pd.5113. [Epub ahead of print] Review. PubMed PMID: 28695637.

2016

Colquitt JL, Morris SA, Denfield SW, Fraser CD, Wang Y, Kyle WB. Survival in Children with Down Syndrome Undergoing Single-Ventricle Palliation. Ann Thorac Surg. 2016 May;101(5):1834-41. doi: 10.1016/j.athoracsur.2015.11.047. Epub 2016 Feb 9. PubMed PMID: 26867706.

Ezon DS, Ayres NA, Altman CA, Denfield SW, Morris SA, Maskatia SA. Echocardiographic Parameters and Outcomes in Primary Fetal Cardiomyopathy. J Ultrasound Med. 2016 Sep;35(9):1949-55. PMID: 27466259.

Lara DA*, Fixler DE, Ethen MK, Canfield MA, Nembhard WN, Morris SA. Prenatal diagnosis, hospital characteristics, and mortality in transposition of the great arteries. Birth Defects Res A Clin Mol Teratol. 2016 Sep;106(9):739-48. PMID: 27296724.

Lara DA, Morris SA, Maskatia SA, Challman M, Nguyen M, Feagin DK, Schoppe L, Zhang J, Bhatt A, Sexson-Tejtel SK, Lopez KN, Lawrence EJ, Andreas S, Wang Y, Belfort MA, Ruano R, Ayres NA, Altman CA, Aagaard KM, Becker J. Pilot study of chronic maternal hyperoxygenation and effect on aortic and mitral valve annular dimensions in fetuses with left heart hypoplasia. Ultrasound Obstet Gynecol. 2016 Sep;48(3):365-72. PMID: 26700848.

Maskatia SA, Pignatelli RH, Ayres NA, Altman CA, Sangi-Haghpeykar H, Lee W. Longitudinal Changes and Interobserver Variability of Systolic Myocardial Deformation Values in a Prospective Cohort of Healthy Fetuses across Gestation and after Delivery. J Am Soc Echocardiogr. 2016 Jan 12. PMID: 26797677.

Maskatia SA, Pignatelli RH, Ayres NA, Altman CA, Sangi-Haghpeykar H, Lee W. Fetal and Neonatal Diastolic Myocardial Strain Rate: Normal Reference Ranges and Reproducibility in a Prospective, Longitudinal Cohort of Pregnancies. J Am Soc Echocardiogr. 2016 Jul;29(7):663-9. PMID: 27049665.  

Maskatia SA, Ruano R, Shamshirsaz AA, Javadian P, Kailin JA, Belfort MA, Altman CA, Ayres NA. Estimated combined cardiac output and laser therapy for twin-twin transfusion syndrome. Echocardiography. 2016 Oct;33(10):1563-1570. doi: 10.1111/echo.13304. Epub 2016 Oct 19. PubMed PMID: 27759174.  

Maskatia SA, Lee W, Altman CA, Ayres NA, Feagin DK, Pignatelli RH. Left ventricular rotational mechanics in early infancy: Normal reference ranges and reproducibility of peak values and time to peak values. Early Hum Dev. 2017 Jan;104:39-44. doi: 10.1016/j.earlhumdev.2016.11.004. Epub 2016 Dec 30. PubMed PMID: 28042971.  

Moaddab A, Tonni G, Grisolia G, Bonasoni MP, Araujo Júnior E, Rolo LC, Prefumo F, de la Fuente S, Sepulveda W, Ayres N, Ruano R. Predicting outcome in 259 fetuses with agenesis of ductus venosus - a multicenter experience and systematic review of the literature. J Matern Fetal Neonatal Med. 2016 Jan 26:1-35. [Epub ahead of print] PubMed PMID: 26809266.

Moffett BS, Garrison JM, Hang A, Morris SA, Tsang R, Dinh K, Griffiths P, Bronicki R, Checchia PA. Prostaglandin Availability and Association with Outcomes for Infants with Congenital Heart Disease. Pediatr Cardiol. 2016 Feb;37(2):338-44. PMID:  26499357.

Riehle-Colarusso TJ, Bergersen L, Broberg CS, Cassell CH, Gray DT, Grosse SD, Jacobs JP, Jacobs ML, Kirby RS, Kochilas L, Krishnaswamy A, Marelli A, Pasquali SK, Wood T, Oster ME; Congenital Heart Public Health Consortium. Databases for Congenital Heart Defect Public Health Studies Across the Lifespan. J Am Heart Assoc. 2016 Oct 26;5(11). pii: e004148. Review. PubMed PMID: 27912209; PubMed Central PMCID: PMC5210337.

Yilmaz B, Narayan HK, Wilpers A, Wiess C, Fifer WP, Williams IA. Electrocardiographic intervals in foetuses with CHD. Cardiol Young. 2016 Jan;26(1):84-9. PMID: 25599806; PMCID: PMC4687898.  

Villafañe J, Lantin-Hermoso MR, Bhatt AB, Tweddell JS, Geva T, Nathan M, Elliott MJ, Vetter VL, Paridon SM, Kochilas L, Jenkins KJ, Beekman RH 3rd, Wernovsky G, Towbin JA; American College of Cardiology’s Adult Congenital and Pediatric Cardiology Council. D-transposition of the great arteries: the current era of the arterial switch operation. J Am Coll Cardiol. 2014 Aug 5;64(5):498-511. doi: 10.1016/j.jacc.2014.06.1150. Review. PubMed PMID: 25082585; PubMed Central PMCID: PMC4340094.

2015

Altman CA. Appropriate Use Criteria: Vital New Link in the Chain of Quality in Pediatric Echocardiography. J Am Coll Cardiol. 2015 Sep 8;66(10):1141-3. doi: 10.1016/j.jacc.2015.07.029. PubMed PMID: 26337993.

Lara D, Morris SA, Maskatia SA, Challman M, Nguyen M, Feagin DK, Schoppe L, Zhang J, Bhatt A, Sexson-Tejtel SK, Lopez KN, Lawrence EJ, Andreas S, Wang Y, Belfort M, Ruano R, Ayres NA, Altman C, Aagaard K, Becker J. A pilot study of chronic maternal hyperoxygenation and effect on aortic and mitral valve annular dimensions in fetuses with left heart hypoplasia. Ultrasound Obstet Gynecol. 2015 Dec 23. PubMed PMID: 26700848.

Donofrio MT, Rychik J; Fetal Heart Society Governing Board and Steering Committee. Multidisciplinary Collaboration in Fetal Cardiovascular Research: The Time Has Come. J Am Soc Echocardiogr. 2016 Feb;29(2):140-2. PMID: 26711365.  

Moffett BS, Garrison JM, Hang A, Morris SA, Tsang R, Dinh K, Griffiths P, Bronicki R, Checchia PA. Prostaglandin Availability and Association with Outcomes for Infants with Congenital Heart Disease. Pediatr Cardiol. 2015 Oct 24. [Epub ahead of print] PubMed PMID: 26499357.

Freud LR, Escobar-Diaz MC, Kalish BT, Komarlu R, Puchalski MD, Jaeggi ET, Szwast AL, Freire G, Levasseur SM, Kavanaugh-McHugh A, Michelfelder EC, Moon-Grady AJ, Donofrio MT, Howley LW, Tierney ES, Cuneo BF, Morris SA, Pruetz JD, van der Velde ME, Kovalchin JP, Ikemba CM, Vernon MM, Samai C, Satou GM, Gotteiner NL, Phoon CK, Silverman NH, McElhinney DB, Tworetzky WOutcomes and Predictors of Perinatal Mortality in Fetuses With Ebstein Anomaly or Tricuspid Valve Dysplasia in the Current Era: A Multicenter Study. Circulation. 2015 Aug 11;132(6):481-9. PMID: 26059011.

Lopez KN, Marengo LK, Canfield MA, Belmont JW, Dickerson HA. Racial disparities in heterotaxy syndrome. Birth Defects Res A Clin Mol Teratol. 2015 Nov;103(11):941-50. doi: 10.1002/bdra.23416. Epub 2015 Sep 2. PubMed PMID: 26333177.

Moon-Grady AJ, Morris SA, Belfort M, Chmait R, Dangel J, Devlieger R, Emery S, Frommelt M, Galindo A, Gelehrter S, Gembruch U, Grinenco S, Habli M, Herberg U, Jaeggi E, Kilby M, Kontopoulos E, Marantz P, Miller O,Ota.o L, Pedra C, Pedra S, Pruetz J, Quintero R, Ryan G, Sharland G, Simpson J, Vlastos E, Tworetzky W, Wilkins-Haug L, Oepkes D; International Fetal Cardiac Intervention Registry. International Fetal Cardiac Intervention Registry: A Worldwide Collaborative Description and Preliminary Outcomes. J Am Coll Cardiol. 2015 Jul 28;66(4):388-99. doi: 10.1016/j.jacc.2015.05.037. PubMed PMID: 26205597.

Ruano R, Javadian P, Kailin JA, Maskatia SA, Shamshirsaz AA, Cass DL, Zamora IJ, Sangi-Haghpeykar H, Lee TC, Ayres NA, Mehollin-Ray A, Cassady CI, Fernandes C, Welty S, Belfort MA, Olutoye OO. Congenital heart anomaly in newborns with congenital diaphragmatic hernia:A single-center experience. Ultrasound Obstet Gynecol. 2015 Jun;45(6):683-8. Epub 2015 May 4.

Kaul B, Sheikh F, Zamora IJ, Mehollin-Ray AR, Cassady CI, Ayres NA, Cass DL, Olutoye OO. 5, 4, 3, 2, 1: embryologic variants of pentalogy of Cantrell. J Surg Res. 2015 Nov;199(1):141-8. doi: 10.1016/j.jss.2015.04.017. Epub 2015 Apr 9. PubMed PMID: 25959837.

Yilmaz B, Narayan HK, Wilpers A, Wiess C, Fifer WP, Williams IA. Electrocardiographic intervals in foetuses with CHD. Cardiol Young. 2016 Jan;26(1):84-9. doi: 10.1017/S1047951114002686. Epub 2015 Jan 20. PubMed PMID: 25599806; PubMed Central PMCID: PMC4687898.

2014

Espinoza J, Lee W,Vials F, Martinez JM, Bennasar M, Rizzo G, Belfort M Collaborative study of 4-dimensional fetal echocardiography in the first trimester of pregnancy. J Ultrasound Med. 2014;33:1079-84. PMID: 24866615.

Donofrio MT, Moon-Grady AJ, Hornberger LK, Copel J, Sklansky MS, Abuhamad A, Cuneo BF, Huhta JC, Jonas RA, Krishnan A, Lacey DO, Lee W, Michelfelder EC, Rempel GR, Silverman NH, Spray TL, Strassburger JF, Tworetzky W, Rychik J. Diagnosis and treatment of fetal cardiac disease. A scientific statement from the American Heart Association. Circulation. 2014; 129: 2183-242.

Lara DA, Lopez KN. Public health research in congenital heart disease. Congenit Heart Dis. 2014 Nov-Dec;9(6):549-58. doi: 10.1111/chd.12235. Epub 2014 Nov 7. Review. PubMed PMID: 25377072.

Morris SA, Ethen MK, Penny DJ, Canfield MA, Minard CG, Fixler DE, Nembhard WN. Circulation. 2014 Jan 21;129(3):285-92. PMID: 24135071. Prenatal diagnosis, birth location, surgical center, and neonatal mortality in infants with hypoplastic left heart syndrome.

Pignatelli RH, Texter KM, Denfield SW, Grenier MA, Altman CA, Ayres NA, Chandra-Bose Reddy S. LV Noncompaction in Ebstein's anomaly in infants and outcomes. JACC Cardiovasc Imaging. 2014 Feb;7(2):207-9. doi: 10.1016/j.jcmg.2013.05.021. PubMed PMID: 24524749.  

Salmanian B, Shamshirsaz AA, Cass DL, Javadian P, Ruano R, Ayres NA, Mehollin-Ray A, Belfort MA. Fetal cardiac tamponade in a case of right-side congenital diaphragmatic hernia. Obstet Gynecol. 2014 Feb;123(2 Pt 2 Suppl 2):447-50. doi: 10.1097/AOG.0000000000000098. PubMed PMID: 24413239.  

2013

Cass DL, Olutoye OO, Cassady CI, Zamora IJ, Ivey RT, Ayres NA, Olutoye OA, Lee TC. EXIT-to-resection for fetuses with large lung masses and persistent mediastinal compression near birth. J Pediatr Surg. 2013 Jan;48(1):138-44. doi: 10.1016/j.jpedsurg.2012.10.067. PubMed PMID: 23331806.  

Hamill N, Romero R, Hassan S, Lee W, Myers SA, Mittal P, Kusanovic JP, Balasubramaniam M, Chaiworapongsa T, Vaisbuch E, Espinoza J, Gotsch F, Goncalves LF, Mazaki-Tovi S, Erez O, Hernandez-Andrade E, Yeo L. The fetal cardiovascular response to increased placental vascular impedance to flow determined with 4-dimensional ultrasound using spatiotemporal image correlation and virtual organ computer-aided analysis. Am J Obstet Gynecol. 2013; 208:153.e1-13.

AIUM practice guideline for the performance of fetal echocardiography. Task Force Chair. American Institute of Ultrasound in Medicine. J Ultrasound Med. 2013; 32: 1067–1082.

Lee W. Referee commentary. Sotiriadis A, Papatheodorou S, Eleftheriades M, Makrydimas G. Re: Nuchal translucency and major congenital heart defects in fetuses with normal karyotype: A meta-analysis. Ultrasound Obstet Gynecol. 2013; 42: 373.

Chaoui R, Copel JA, DeVore GR, Hecher K, Lee W, Munoz H, Paladini D, Tutschek B, Yagel S. ISUOG Practice Guidelines (updated): Sonographic screening examination of the fetal heart. Carvalho JS, Allan LD, Ultrasound Obstet Gynecol. 2013; 41: 348-59.

2012

Cass DL, Olutoye OO, Ayres NA, Moise KJ Jr, Altman CA, Johnson A, Cassady CI, Lazar DA, Lee TC, Lantin MR. Defining hydrops and indications for open fetal surgery for fetuses with lung masses and vascular tumors. J Pediatr Surg. 2012 Jan;47(1):40-5. doi: 10.1016/j.jpedsurg.2011.10.019. PubMed PMID: 22244390.  

2011

Lazar DA, Cass DL, Dishop MK, Adam K, Olutoye OA, Ayres NA, Cassady CI, Olutoye OO. Fetal lung interstitial tumor: a cause of late gestation fetal hydrops. J Pediatr Surg. 2011 Jun;46(6):1263-6. doi: 10.1016/j.jpedsurg.2011.02.056. PubMed PMID: 21683234. 

Cass DL, Olutoye OO, Cassady CI, Moise KJ, Johnson A, Papanna R, Lazar DA, Ayres NA, Belleza-Bascon B. Prenatal diagnosis and outcome of fetal lung masses.  J Pediatr Surg. 2011 Feb;46(2):292-8. doi: 10.1016/j.jpedsurg.2010.11.004. PubMed PMID: 21292076.  

2000-2010

Naik-Mathuria B, Chang S, Fitch ME, Westhoff J, Brandt ML, Ayres NA, Olutoye OO, Cass DL. Patent ductus arteriosus ligation in neonates: preoperative predictors of poor postoperative outcomes. J Pediatr Surg. 2008 Jun;43(6):1100-5. doi: 10.1016/j.jpedsurg.2008.02.037. PubMed PMID: 18558190.  

Falkensammer CB, Ayres NA, Altman CA, Ge S, Bezold LI, Eidem BW, Kovalchin JP. Fetal cardiac malposition: incidence and outcome of associated cardiac and extracardiac malformations. Am J Perinatol. 2008 May;25(5):277-81. doi: 10.1055/s-2008-1066874. Epub 2008 Apr 9. PubMed PMID: 18401841.  

Slesnick TC, Ayres NA, Altman CA, Bezold LI, Eidem BW, Fraley JK, Kung GC, McMahon CJ, Pignatelli RH, Kovalchin JP. Characteristics and outcomes of fetuses with pericardial effusions. Am J Cardiol. 2005 Aug 15;96(4):599-601. PubMed PMID: 16098320.  

John JB, Bricker JT, Fenrich AL, Vick GW, El-Said HG, Ayres NA, Bezold LI. Images in cardiovascular medicine. Fetal diagnosis of right ventricular aneurysm associated with supraventricular tachycardia with left bundle-branch block aberrancy. Circulation. 2002 Jul 2;106(1):141-2. PubMed PMID: 12093784.  

Kovalchin JP, Lewin MB, Bezold LI, Altman CA, Ayres NA. Harmonic imaging in fetal echocardiography. J Am Soc Echocardiogr. 2001 Oct;14(10):1025-9. PubMed PMID: 11593208.  

Nowlen TT, Ayres NA, Kearney DL, Nihill MR, Grifka RG. Premature closure of the foramen ovale associated with aortic stenosis, left ventricular dilation with thrombus, and early mortality. Am J Cardiol. 2000 May 1;85(9):1159-61, A9. PubMed PMID: 10781774.