Luc Joyeux, MD, PhD


Catholic University of LeuvenPostgraduate EducationDSc-PhD Doctor of Biomedical Sciences2020
Great Ormond Street Hospital for Children, LondonFellowshipPediatric Surgery2019
University of Dijon - BurgundyFellowshipPediatric Surgery2014
University of Dijon - BurgundyResidencyPediatric Surgery2011
Children's Hospital of PhiladelphiaResearch FellowshipFetal Surgery2009
Universities of Paris XI and Paris XIIMScMaster of Biomedical Sciences2009
Montpellier 1 University, Faculty of MedicineInternshipMedical Studies2005
Montpellier 1 University, Faculty of MedicineMedical SchoolMaster of Medical Science2005
University of Dublin, Trinity College Dublin, School of MedicineInternshipMedical Studies2002


Dr. Joyeux was born in Montpellier, France in a family that has produced three generations of surgeons.  He developed a special interest in children's care and research, always questioning himself and current medical knowledge to solve medical problems and improve care.  He trained in Dijon, Paris, and London, becoming a board-certified general pediatric surgeon in France and practicing in France and Belgium.  He completed a PhD and training in fetal surgery in Leuven, Belgium, the largest research and clinical fetal center in Europe, and was appointed to the position of fetal surgeon at that center.

He is experienced in managing standard neonatal, pediatric abdominal, thoracic and fetal surgical conditions and is licensed in Texas as a general pediatric surgeon and fetal surgeon.  He is also an international translational research scientist with expertise in bringing surgical innovations to fetal and pediatric patients.

Dr Joyeux's main research interests are to develop large animal disease models for fetal conditions amenable to surgery; fetoscopic surgery for spina bifida, congenital diaphragmatic hernia and complex gastroschisis; fetal surgery for vein of Galen malformation; surgical training, learning curve and competency analyses in fetal and pediatric surgeries; and cost-effectiveness in surgery. He is also developing a patented biomedical device to completely close port sites in fetal, pediatric and adult laparoscopic surgeries.

Dr Joyeux is passionate about caring for young patients - especially babies in the womb - and their parents and families, and developing new surgical treatments to improve their quality of life. "Being blessed with an amazing wife and five wonderful children, I always listen to the patient and their families, and consider and treat each patient like my own children." he says.

Clinical Interests:

Fetal Surgery
Maternal-Fetal Medicine
Neonatal surgery
Digestive and Thoracic Pediatric Surgery
Minimally-Invasive & Robotic Pediatric & Fetal Surgery

Research Interests:

Translational Research
Animal Disease Models
Surgical Innovation & Surgical competency-based Training
Surgical data sciences
Fetal therapy for Open Spina Bifida
Fetal therapy for Gastroschisis
Fetal therapy for Congenital Diaphragmatic Hernia
Fetal therapy for Occipital Encephalocele
Fetal therapy for Vein of Galen Malformation and other ArterioVenous Malformations
Fetal therapy for SacroCoccygeal Teratoma
Biomedical devices in laparoscopic and fetal surgery


Organization NameRole
Association Nationale Spina Bifida et Handicaps Associés (ASBH), FranceScientific Board Member (2014-Present)
Belgian Association of Paediatric Surgery (BELAPS)Member (2015-Present)
European Pediatric Surgery Association (EUPSA)Member (2018-Present)
European Society of Pediatric Endoscopic Surgeons (ESPES)Member (2013-Present)
Expertscape Expert in Spinal DysraphismMember (2021-Present)
French Society of Pediatric Surgery (Société Francaise de Chirurgie Pédiatrique) (SFCP)Member (2013-Present)
International Fetal Medicine and Surgery Society (IFMSS)Member (2015-Present)
Study Group in Pediatric Celioscopic surgery (Groupe d’Etude en Coeliochirurgie Infantile) (GECI)Member (2013-Present)
Surgical Data Science InitiativeMember (2021-Present)

Selected Publications

L. Joyeux, J. van der Merwe, M. Aertsen, P. A. Patel, A. Khatoun, M. G. M. C. Mori da Cunha, S. De Vleeschauwer, J. Parra, E. Danzer, M. Mc Laughlin, D. Stoyanov, T. Vercauteren, S. Ourselin, P. de Coppi, E. Radaelli, F. Van Calenbergh, J. Deprest. Neuroprotection is improved by watertightness of spina bifida repair in the fetal lamb. Ultrasound Obstet Gynecol. 2022, March 30. doi: 10.1002/uog.24907

L. Joyeux, D. Basurto, T. Bleeser, L. Van der Veeken, S. Vergote, Y. Kunpalin, L. Trigo, E. Corno, F. De Bie, P. de Coppi, S. Ourselin, F. Van Calenbergh, S. Hooper, S. Rex, J. Deprest. Simulated fetoscopic spina bifida repair is safe under heated-humidified carbon dioxide insufflation and controlled anesthesia maintaining maternal physiological homeostasis in fetal lamb. Prenat Diagn 2022 Feb;42(2):180-191. doi: 10.1002/pd.6093. Epub 2022 Jan 19.

L. Maier-Hein, M. Eisenmann, D. Sarikaya, K. März, T. Collins, A. Malpani, J. Fallert, H. Feussner, S. Giannarou, P. Mascagni, H. Nakawala, A. Park, C. Pugh, D. Stoyanov, S. S. Vedula, K. Cleary, G. Fichtinger, G. Forestier, B. Gibaud, T. Grantcharov, M. Hashizume , D. Heckmann-Nötzel, H. Kenngott, R. Kikinis, L. Mündermann, N. Navab, S. Onogur, R. Sznitman, R. Taylor, M. D. Tizabi, M. Wagner, G. D. Hager, T. Neumuth, N. Padoy, J. Collins, I. Gockel, J. Goedeke, D. Hashimoto, L. Joyeux, K. Lam, D. Leff, A. Madani, H. J. Marcus, O. Meireles, A. Seitel, D. Teber, F. Ückert, B. P. Müller-Stich, P. Jannin, S. Speidel. Surgical Data Science – from Concepts towards Clinical Translation. Medical Image Analysis. 2022 Feb. Vol. 76, 102306. doi: 10.1016/

L. Joyeux, M. A. Belfort, P. De Coppi, D. Basurto, I. Valenzuela, A. King, L. De Catte, A. A. Shamshirsaz, J. Deprest, S. G. Keswani. Complex gastroschisis, a new indication for fetal surgery? Ultrasound Obstet Gynecol. 2021, Sept 01. doi: 10.1002/uog.24759

P. De Vloo, L. Joyeux, G.G. Heuer, N.S. Adzick, J. Deprest, F. Van Calenbergh. Letter to the Editor. Open fetal repair for occipital encephalocele: an experimental concept to first assess in animal models. J Neurosurg Pediatr, 1-2. 2021, April 23. doi: 10.3171/2021.1.PEDS2128

D. Basurto, N. Sananes, T. Bleeser, I. Valenzuela, N. De Leon, L. Joyeux, E. Verbeken, S. Vergote, L. Van der Veeken, F. Maria Russo, J. Deprest. Safety and efficacy of the Smart Tracheal Occlusion device in the diaphragmatic hernia lamb model. Ultrasound Obstet Gynecol. 2021, Jan 01. Vol. 57; iss. 1; p. 105 – 112. doi: 10.1002/uog.23135.

Joyeux L, De Bie F, Danzer E, Russo FM, Javaux A, Peralta CFA, De Salles AAF, Pastuszka A, Olejek A, Van Mieghem T, De Coppi P, Moldenhauer J, Whitehead WE, Belfort MA, Lapa DA, Acacio GL, Devlieger R, Hirose S, Farmer DL, Van Calenbergh, F, Adzick NS, Johnson MP, Deprest J. Learning curves of open and endoscopic fetal spina bifida closure: a systematic review and meta-analysis. Ultrasound Obstet Gynecol. 2020 Jun;55(6):730-739. doi: 10.1002/uog.20389. Epub 2019 July 4

Google Scholar Publications

PubMed Publications

Orcid Publications

KU Leuven   Catholic University Leuven


January 2021 (USA): Best oral presentation, research session, during the SMFM 41st Annual meeting, online, USA.  « Neuroprotection is improved by watertightness of spina bifida repair in the fetal lamb »

June 2020 (UK-Belgium): Institutional Translational Partnership Award (iTPA) between the Wellcome Trust and the university KU Leuven to develop preclinical studies and a phase-1 clinical study for a patented biomedical device for port-site closure.

April 25th, 2019: Second Prize-Winner of the award for the best exploitation plan during the training course on “Exploitation of Research: Technology & Knowledge Transfer” from KU Leuven Research & Development. « Revolutionizing minimally invasive surgery with a novel closure device »

July 2018 (USA): Young Investigator Travel Award from the IFMSS for its 37th Annual meeting in Bali, Indonesia.  Feasibility and safety of single-port fetoscopy for spina bifida repair in the fetal lamb model »

February 2018 (Belgium): Winning abstract on the Departmental Day of the Department of Development and Regeneration, Biomedical Sciences, KU Leuven, Belgium.  Efficacy of watertight fetal spina bifida repair in the fetal lamb model »

August 2017 (USA): Young Investigator Travel Award from the IFMSS for its 36th Annual meeting in Jackson Hole, WY, USA.  Watertightness is required for experimental fetal spina bifida repair to reverse hindbrain herniation and improve neuromotor function in the lamb model »

April 2017: Broaden Your Horizon travel award from the Doctoral School of Biomedical Sciences, KU Leuven, Belgium. 

October 2015: Best congress communication: BELAPS, Luxembourg.  Fetoscopic versus open repair for spina bifida aperta: a systematic review of outcomes »